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Tuesday, March 19, 2019
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Using the CRISPR methodology, the team turned off the NRF2 sequence in chemotherapy-resistant carcinoma cells. These ar referred to as knockout cells.
The investigators then treated a batch of the genetically altered carcinoma cells and a batch of unaltered cancer cells with cisplatin.
The unaltered cells continued to grow and multiply, even when being treated with cisplatin at increasing doses.
Cell growth solely slowed at the best concentrations of therapy. In distinction, even low doses of cisplatin halted replication of the genetically altered carcinoma cells. The scientists recurrent the experiment with carboplatin and noted similar results.
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